您的位置: 首页 > 农业专利 > 详情页

АГЕНТЫ, СВЯЗЫВАЮЩИЕ БЕЛКИ R-СПОНДИНЫ (RSPO), И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
专利权人:
ОНКОМЕД ФАРМАСЬЮТИКАЛС; ИНК. (US)
发明人:
ГАРНИ Остин Л. (US),АКСЕЛЬРОД Фумико Такада (US),ХОЭЙ Тимоти Чарльз (US),ШАРТЬЕ-КУРТО Сесиль (US)
申请号:
RU2014101669/10
公开号:
RU2014101669A
申请日:
2012.07.13
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. An isolated antibody that specifically binds R-spondin 2 persons (RSPO2), comprising: (a) CDR1 heavy chain comprising SSYAMS (SEQ ID NO: 29), CDR2 of the heavy chain comprising SISSGGSTYYPDSVKG (SEQ ID NO: 30) and heavy chain CDR3 comprising RGGDPGVYNGDYEDAMDY (SEQ ID NO: 31) and (b) CDR1 light chain comprising KASQDVSSAVA (SEQ ID NO: 32), CDR2 of the light chain comprising WASTRHT (SEQ ID NO: 33) .2, comprising QQHYSTP (34, SEQ ID NO) and light chain CDR3. An antibody according to claim 1 comprising:. (A) heavy chain variable region, characterized by at least 90% identity with the sequence SEQ ID NO: 63 and a variable light chain, characterized by at least 90% identity with the sequence SEQ ID NO: 76 (b) a heavy chain variable region, characterized by at least 90% sequence identity with SEQ ID NO: 63 and a light chain variable region, characterized by at least 90% sequence identity with SEQ ID NO: 67 or (c) a heavy chain variable region, characterized by at least 90% sequence identity with SEQ ID NO: 27 and a light chain variable region, characterized by at least 90% sequence identity with SEQ ID NO: 28.3. An antibody according to claim 1, comprising: (a) the heavy chain variable region with the sequence SEQ ID NO: 63 and a light chain variable region to SEQ sequences ID NO:. 76 (b) heavy chain variable region with the sequence SEQ ID NO: 63 and variable light chain sequence of SEQ ID NO: 67 or (c) a heavy chain variable region with the sequence SEQ ID NO: 27 and a variable light chain sequence of SEQ ID NO: 28.4. An antibody according to Claim. 1, which inhibits binding RSPO2 with at least one RECEP1. Изолированное антитело, которое специфично связывает R-спондин 2 человека (RSPO2), содержащее: (a) CDR1 тяжелой цепи, включающий SSYAMS (SEQ ID NO: 29), CDR2 тяжелой цепи, включающий SISSGGSTYYPDSVKG (SEQ ID NO: 30), и CDR3 тяжелой цепи, включающий RGGDPGVYNGDYEDAMDY (SEQ ID NO: 31) и(b) CDR1 легкой цепи, включающий KASQDVSSAVA (SEQ ID NO: 32), CDR2 легкой цепи, в
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充