BOWMAN, EDWARD P.,CHEN, SHI-JUAN,CUA, DANIEL J.,MOORE, KEVIN W.,CHURAKOVA, TATYANA,NGUYEN, HONG-NHUNG Y.,CHAN, JASON R.
申请号：
CA2506672
公开号：
CA2506672C
申请日:
2003.12.18
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
It is provided methods of treatment for skin disorders. In particular,treatment, the skindisorders are generally inflammatory skin disorders, including improper woundhealing. Itis further provided the use of an IL-23 complex for treating a cutaneouswound, the IL-2-3complex comprising a polypeptide comprising residues 352 to 521 of SEQ ID NO:8 or aconservatively modified variant thereof comprising an individual amino acidsubstitution；and a polypeptide comprising residues 25 to 330 of SEQ ID NO: 8 or aconservativelymodified variant thereof comprising an individual amino acid substitution. Itis alsoprovided the use of an IL-23 fusion protein for treating a cutaneous wound,the IL-23fusion protein comprising residues 352 to 521 of SEQ ID NO: 8 and residues 25to 330of SEQ ID NO: 8.
