Curators of the University of Missouri;Washington University;The Research Foundation for The State University of New York
发明人:
Jianmin Cui,Ira S. Cohen,Xiaoqin Zou
申请号：
US15137627
公开号：
US20160228411A1
申请日:
2016.04.25
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present disclosure relates to methods and compositions for modulating the activity of KCNQ channels as a means for reducing the effects of aberrant KCNQ channel function associated with epilepsy, deafness and arrhythmias including but not limited to, Long-QT syndrome (“LQTS”), and atrial fibrillation. The present disclosure also relates to the discovery of certain regions of KCNQ channels that interact with various channel stimulating molecules such as, ATP, and PIP2, as well as KCNQ channel domains that effect voltage dependant channel activation. The disclosure is also directed to the use of small molecules to modulate KCNQ channel activity in a cell. Moreover, the present disclosure relates to the therapeutic effects of treating a subject with modulators of KCNQ channel activity.
