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Method of predicting development and severity of graft-versus-host disease
专利权人:
发明人:
Heinrich Röder,Joanna Röder
申请号:
US14949229
公开号:
US09563744B1
申请日:
2015.11.23
申请国别(地区):
US
年份:
2017
代理人:
摘要:
A classifier and method for predicting or characterizing graft-versus-host disease in a patient after receiving a transplant of pluripotent hematopoietic stem cells or bone marrow. The classifier operates on mass-spectral data obtained from a blood-based sample of the patient and is configured as a combination of filtered mini-classifiers using a regularized combination method, such as logistic regression with extreme drop-out. The method also uses a “deep-MALDI” mass spectrometry technique in which the blood-based samples are subject to at least 100,000 laser shots in MALDI-TOF mass spectrometry in order to reveal greater spectral content and detect low abundance proteins circulating in serum associated with graft-versus-host disease.
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中国工程科技知识中心
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