PURPOSE: A topical injection composition for endoscope demucosation is provided to extend uplift time of mucous lesion part and to enhance operationality. CONSTITUTION: A topical injection composition for endoscope demucosation comprises alginate and cation. Cation is cation or the salt of calcium, potassium, sodium, barium, magnesium, gadolinium, lithium, copper, iron, aluminum, strontium, tin, zinc, chrome or organic cation, calcium glutaminate, poly(amino acid), poly(ethylene imine), poly(vinylamine), poly(allyl amine) or polysaccharide. Cation is included in a form of calcium-gluconate, calcium chloride(CaCl2), barium chloride(BaCl2) or magnesium chloride(MgCl2). The hydrogel composition additionally includes nano-particles. The nano-particle is gadolinium nano-particle, iron oxide nano-particle, barium nano-particle, gold or nano-silver particle, gadolinium oxide, barium sulfate, and silica nano-particle or iodine nano-particle. The endoscope demucosation is operated on esophageal cancer, stomach cancer, mamillary region cancer or colon cancer.본 발명은 내시경적 점막 절제술(endoscopic mucosal resection, EMR)에 사용되는 주사제 조성물에 관한 것으로, 보다 구체적으로, 알지네이트 및 양이온을 포함하는 내시경적 점막 절제술용 하이드로젤 주사제 조성물에 관한 것이다.
