IT IS AN OBJECT OF THE PRESENT INVENTION TO PROVIDE A THERAPEUTICALLY EFFECTIVE AGENT FOR THERAPY AND/OR IMPROVEMENT OF DIC, OR A METHOD FOR TREATING AND/OR IMPROVING DIC. THE PRESENT INVENTION PROVIDES AN AGENT FOR THERAPY AND/OR IMPROVEMENT OF DISSEMINATED INTRAVASCULAR COAGULATION COMPRISING THROMBOMODULIN AS AN ACTIVE INGREDIENT, WHICH IS ADMINISTERED TO ANTITHROMBIN-REDUCED PATIENTS HAVING A LOW PLASMA ANTITHROMBIN ACTIVITY OF LESS THAN 50%.