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METHOD FOR PRODUCING STARCH GRANULES, AND ORALLY DISINITEGRATING TABLET
专利权人:
发明人:
Masao Umezaki,Hiroshige Murase,Toshio Uno,Toshiyuki Niwa
申请号:
US14397042
公开号:
US20150141525A1
申请日:
2013.04.23
申请国别(地区):
US
年份:
2015
代理人:
摘要:
A method for producing starch granules suitable as an excipient for an orally disintegrating tablet. Fluidized bed granulation is performed by spraying a starch paste in small amounts while a β-starch is being fluidized using an air-fluidized bed. Subsequently, fluidized bed drying is performed at a temperature equal to or higher than the gelatinization temperature of the β-starch. This yields starch granules having a high degree of gelatinization in comparison with the amount of α-starch adhered to the β-starch by the spraying of the starch paste. These starch granules alone impart satisfactory oral disintegratability and breaking strength to the tablet. Accordingly, when used as an excipient during tableting of orally disintegrating tablets, other auxiliary excipients such as saccharides or crystalline cellulose need not be added.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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