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METHOD FOR PRODUCING STARCH GRANULES, AND ORALLY DISINTEGRATING TABLET
专利权人:
Japan Corn Starch Co.; Ltd.
发明人:
申请号:
EP13781762.3
公开号:
EP2842986B1
申请日:
2013.04.23
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
A method for producing starch granules suitable as an excipient for an orally disintegrating tablet. A paste is sprayed in small amounts while β-starch is being fluidized using an air-fluidized bed to carry out fluidized bed granulation. Thereafter, fluidized bed drying is carried out at the gelatinization temperature of the β-starch or higher. This results in starch granules having a high degree of gelatinization in comparison with the amount of gelatinized starch adhered to the β-starch by the spraying of the paste. These starch granules alone impart an adequate oral disintegration performance and breaking strength to the tablet. Consequently, in instances of use as an excipient for tableting of orally disintegrating tablets, another auxiliary excipient such as crystalline cellulose or a sugar or the like need not be added.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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