Fumarate salt of 9- [4- (3-chloro-2-fluoro-phenylamino) -7-methoxy-quinazolin-6-yloxy] -1,4-diaza-spiro [5.5] undecan-5-one , Its use and preparation as drugs
The present invention has the following pharmacological properties, in particular the compounds of formula (I) ## STR1 ## which have an inhibitory effect on signal transduction mediated by tyrosine kinases, and these compounds, particularly suitable for inhalation. The present invention relates to the stereoselective preparation process of pharmaceutical preparations and their use for the treatment of diseases, in particular neoplastic diseases, benign prostatic hypertrophy and diseases of the lungs and airways. [Selection figure] None本発明は、有益な薬理学的特性、特にチロシンキナーゼによって媒介されるシグナル伝達に対する阻害効果を有する、下記式(I)【化１】(I)の化合物、及びこれらの化合物、特に吸入に適した医薬製剤の立体選択的調製プロセス、並びに疾患、特に腫瘍性疾患、良性前立腺肥大症及び肺と気道の疾患の治療のためのそれらの使用に関する。【選択図】なし
