The present invention considers a method and an apparatus where a secure stand-alone microdevice or a microdevice as part of a larger processing device is arranged for prevention of tampering, unauthorized use, and unauthorized extraction of information from one or more information containing regions of the secured microdevice by controlled obliteration of the information in the information containing region. The method implements control protocols and hardware which monitor the conditions of secured microdevices and generate commands to trigger said controlled obliteration of information； establishes a local energy storage device which stores energy to be used to perform said controlled obliteration of information； establishes localized controlled release of the stored energy from the local energy storage device and at least partial deposition of the stored energy in the proximity of the information containing regions of the secured microdevices upon generation of a command to trigger said controlled obliteration of information； and maintains conditions for controlled release of the energy stored in the local energy storage upon generation of a command to trigger said controlled obliteration of information for the duration of time necessary to achieve desired controlled obliteration of said information.Даний винахід стосується нових макроциклічних сполук і способів їхнього застосування.Даний винахід додатково стосується фармацевтичних композицій, що містять сполуки за даним винаходом або їх фармацевтично прийнятні солі, складні ефіри або пролікарські засоби, у поєднанні з фармацевтично прийнятним носієм або ексципієнтом.
