Floris Louis VAN DELFT,Remon VAN GEEL,Maria Antonia WIJDEVEN,Jorge Merijn Mathieu VERKADE,Ryan HEESBEEN
申请号：
US15029123
公开号：
US20160280797A1
申请日:
2014.10.14
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The invention relates to a glycoprotein comprising an optionally fucosylated glycan according to formula (105) or (106), wherein Su(A)x is a modified sugar moiety comprising one or more functional groups A. Functional group A is independently selected from the group consisting of a thiol group, a halogen, a sulfonyloxy group, a halogenated acetamido group, a mercaptoacetamido group and a sulfonated hydroxyacetamido group. The invention also relates to a glycoprotein-conjugate wherein a glycoprotein according to the invention is conjugated to a molecule of interest. Said molecule of interest may for example be an active substance. The invention further relates to a process for the preparation of a modified glycoprotein, and to a method for the preparation of a glycoprotein-conjugate. The invention particularly relates to modified antibodies, antibody-conjugates, antibody-drug conjugates and methods for the preparation thereof.
