COMPOUNDS OF 1-CYANO-PYRROLIDINES AS USP30 INHIBITORS

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专利权人:

发明人:

申请号：

RU2017134901

公开号：

RU2017134901A3

申请日:

申请国别(地区):

RU

年份:

2019

代理人:

摘要：

The present invention relates to novel compounds and method for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase 30 (USP30). The invention further relates to the use of DUB inhibitors in the treatment of conditions involving mitochondrial dysfunction and cancer. Compounds of the invention include compounds having the formula (II) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R8, R9, R10, R12, Z, Y and m are as defined herein.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/