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1-CYANO-PYRROLIDINE DERIVATIVES AS INHIBITORS OF USP30
专利权人:
MISSION THERAPEUTICS LIMITED
发明人:
Mark Ian KEMP,Martin Lee STOCKLEY,Andrew MADIN
申请号:
US15776149
公开号:
US20200262838A1
申请日:
2016.11.29
申请国别(地区):
US
年份:
2020
代理人:
摘要:
The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylatin-enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase 30 or Ubiquitin Specific Peptidase 30 (USP30). The invention further relates to the use of DUB inhibitors in the treatment of conditions involving mitochondrial dysfunction and cancer. Compounds of the invention include compounds having the formula (I) (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, m, L and X are as defined herein.
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中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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