Jingluweidai Information Consulting Service (Beijing) Co Ltd
发明人:
ZHONG, Bohua,WANG, Jianming,JIN, Xuefeng
申请号：
EP17861072
公开号：
EP3517537A4
申请日:
2017.09.22
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
The present disclosure relates to a compound of Formula I or a non-toxic pharmaceutically acceptable salt thereof, wherein each R1, R2, R3, and R4 is independently selected from methyl (-CH) and trideuteromethyl (-CD), at least one of R1, R2, R3, and R4 is selected from trideuteromethyl (-CD).The compound is a deuterated derivative of L-tetrahydropalmatine, which not only markedly improves pharmacological effects, but also significantly reduces cardiac side effects, liver toxicity, and remarkably decreases individual differences.
