JINGLUWEIDAI INFORMATION CONSULTING SERVICE (BEIJING) CO. LTD.
发明人:
Bohua ZHONG,Jianming WANG,Xuefeng JIN
申请号：
US16383307
公开号：
US20190240204A1
申请日:
2019.04.12
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present disclosure relates to a compound of Formula I or a non-toxic pharmaceutically acceptable salt or solvate thereof, wherein each R1, R2, R3, and R4 is independently selected from methyl (—；CH3) and trideuteromethyl (—；CD3), at least one of R1, R2, R3, and R4 is selected from trideuteromethyl (—；CD3).The compound is a deuterated derivative of L-tetrahydropalmatine, which not only markedly improves pharmacological effects, but also significantly reduces cardiac side effects, liver toxicity, and remarkably decreases individual differences.
