The present invention discloses a disposable endoscope sheath, comprising an insertion portion, a control portion and an endoscope locking portion, wherein the insertion portion comprises a sheath head and a sheath tube the control portion comprises a main body, a water inlet and outlet valve and an instrument adjusting knob and the endoscope locking portion comprises an extension endoscope bridge, a locking sleeve and a protective cover. The sheath head is located at the front end of the insertion portion and is connected with the sheath tube in the rear. The sheath tube is connected with the extension endoscope bridge of the endoscope locking portion through a main body. The water inlet and outlet valve and the instrument adjusting knob are located on the main body of the endoscope sheath. The sheath tube is a multi-channel structure, and the outer surface of the insertion portion has scale marks. The present invention has the beneficial effects in that the disposal use avoids cross infection, and the demands of different endoscopic surgeries can be satisfied.
