Szubsztituált 2-(4-heterociklilbenzil)izoindolin-1-on analógok mint muszkarin acetilkolin receptor M1 pozitív allosztérikus modulátorai

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专利权人:

Vanderbilt University

发明人:

LINDSLEY, Craig, W.,CONN, P., Jeffrey,WOOD, Michael, R.,HOPKINS, Corey, R.,MELANCON, Bruce, J.,POSLUSNEY, Michael, S.,ENGERS, Darren, W.

申请号：

HUE12843949

公开号：

HUE031313T2

申请日:

2012.10.28

申请国别(地区):

HU

年份:

2017

代理人:

摘要：

In one aspect, the invention relates to substituted 2-(4-heterocyclylbenzyl)isoindolin-1-one analogs compounds, derivatives thereof, and related compounds which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M 1 (mAChR M 1 )； synthesis methods for making the compounds； pharmaceutical compositions comprising the compounds； and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.

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