Partha S. Chowdhury,David Tice,Zhan Xiao,Philipp Steiner,Krista Kinneer,Marlon Rebelatto
申请号：
US14359864
公开号：
US20140363429A1
申请日:
2012.11.20
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to antibodies and antigen binding fragments thereof that bind the extracellular domain of the HER3 receptor and inhibit various HER3 receptor related functions via ligand-dependent and/or ligand-independent mechanisms. Also provided are compositions with increased half-life. In addition, the invention provides compositions and methods for diagnosing and treating diseases associated with HER3 mediated signal transduction.
