Hayes, John William,Wotton, Paul,Sadowski, Peter L.
申请号：
AU2013203802
公开号：
AU2013203802A1
申请日:
2013.04.11
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
#$%^&*AU2013203802A120130509.pdf#####Abstract A hazardous agent injection system, the hazardous agent injection system comprising: a medicament in an amount of from about 0.02 ml to about 4.0 ml a powered injector, the powered jet injector comprising: a container configured to contain the medicament an injection outlet member associated with the container, the injection outlet member including an injection-assisting needle configured to pierce the skin of a patient and deliver a jet of medicament to the patient subcutaneously a firing mechanism associated with the container and configured to expel the medicament from the container through the outlet member for injecting the medicament an energy source associated with the firing mechanism and configured to power the firing mechanism and to jet inject the medicament from the injection outlet member as a fluid jet and a trigger mechanism associated with the firing mechanism and configured to activate the firing mechanism, wherein the powered injector is configured to eject the medicament from the injection outlet member such that one or more of confidence intervals of (a) the maximum concentration of medicament in blood plasma of a patient following administration of a dose of the medicament to the patient ("Cmax") with the hazardous agent injection system, (b) the time to reach the maximum concentration of medicament in blood plasma of a patient following administration of a dose of the medicament to the patient with the hazardous agent injection system ("Tmax ") and (c) area under the curve of the concentration of medicament in blood plasma of a patient following administration of a dose of the medicament to the patient with the hazardous agent injection system of the injected medicament ("AUC") falls between about 80% and about 125% of a measured confidence interval of the same dose of medicament delivered by a hand-powered syringe.WO 2010/108116 PCT/US2010/028011 2/12 1101 80 64 56 55 84 80 15 1453 58 8 140 52 - 06
