3-(ARYL OR HETEROARYL) METHYLENEINDOLIN-2-ONE DERIVATIVES AS INHIBITORS OF CANCER STEM CELL PATHWAY KINASES FOR THE TREATMENT OF CANCER

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专利权人:

BOSTON BIOMEDICAL; INC.

发明人:

LI, CHIANG, J.,LIU, JI-FENG,LI, WEI,GIBEAU, AMANDA,ROGOFF, HARRY,TSUBOI, KATSUNORI,TAKANASHI, YOSUKE,TOJO, SHINGO,KODAMA, TOMOHIRO,KUBOTA, KATSUMI,KANAI, TOSHIO

申请号：

SG11201507346P

公开号：

SG11201507346PA

申请日:

2014.03.13

申请国别(地区):

SG

年份:

2015

代理人:

摘要：

The invention provides compounds of Formula I as inhibitors of cancer stem cells as well as cancer stem cell pathway kinase and other related kinases, pharmaceutical compositions and uses thereof in the treatment of cancer or a related disorder in a mammal, wherein i.a. R2 is an optionally substituted heterocycle or optionally substituted aryl； and one of R4, R5, R6 and R7 is a substituted heterocycle or substituted aryl.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/