PREYER, Martin,COLTHART, Allison,WEINSTEIN, Pamela,WIENCEK, Patrick,GEIGER, Emma,MEIER, Werner
申请号：
USUS2019/066542
公开号：
WO2020/131697A3
申请日:
2019.12.16
申请国别(地区):
US
年份:
2020
代理人:
摘要：
A Twin Immune Cell Engager (TWICE) is a kit or composition for treating cancer comprising a first component and second component. Each component comprises a targeting moiety that binds a tumor antigen expressed by the cancer or an antigen expressed by a non-cancer cell in the tumor microenvironment. In some embodiments, the first and second components each comprise an immune cell binding domain capable of immune cell binding activity when binding the immune cell binding domain in the other component, and a complementary binding domain capable of binding to a complementary antigen when binding the complementary binding domain in the other component. In some embodiments, the first and/or second components comprise a complementary functional domain with activity when targeted to the cancer cell or its microenvironment. The present TWICE complexes offer a unique ability to combine multiple functions into a two-component complex that becomes activated in the tumor microenvironment. The present complexes, thus, provide meaningful advantages in having a single approach to administering a two-component complex that is localized to the tumor microenvironment and has the ability to effect two different signals to benefit patients. This unique construct offers benefits that were not present in prior art constructs.La présente invention concerne un recruteur de cellules immunitaires jumelles (TWICE) qui est un kit ou une composition permettant de traiter le cancer comprenant un premier constituant et un second constituant. Chaque constituant comprend une fraction de ciblage qui se lie à un antigène tumoral exprimé par le cancer ou un antigène exprimé par une cellule non cancéreuse dans le micro-environnement tumoral. Dans certains modes de réalisation, les premier et second constituants comprennent chacun un domaine de liaison de cellules immunitaires capable d'une activité de liaison de cellules immunitaires lors de la liaison du domaine de liaison de cellules immunitaires dan
