Disclosed is an implantable construct for replacement of a defective bladder in a subject comprising a) a tubular scaffold having a first open end configured for anastomosis to an opening in the subject&rsquos abdominal wall, a second open end configured to connect to a ureter and b) an autologous smooth muscle cell (SMC) population that is not derived from the defective bladder, deposited on or in a surface of the tubular scaffold, wherein the cell population is a smooth muscle cell population derived from adipose tissue or peripheral blood, and wherein the implantable construct is adapted for temporary storage and passage of urine.
