DALEY, THOMAS E.,戴利 汤玛士E,戴利 湯瑪士E,SQUIERS, ELIZABETH C.,史奎尔司 依丽纱白C,史奎爾司 依麗紗白C,YU, KIN-HUNG PEONY,于 金 皇 波尼,于 金 皇 波尼
申请号：
TW099118855
公开号：
TWI523653B
申请日:
2010.06.09
申请国别(地区):
TW
年份:
2016
代理人:
摘要：
Provided herein are methods of administering 4-methylpyrazole (4-MP), or physiologically acceptable salts thereof, to subjects of genetic subpopulations expressing speciftc polymorphisms of the alcohol dehydrogenase and aldehyde dehydrogenase genes. Also provided herein are methods to prevent or ameliorate ethanol intolerance, reduce or ameliorate symptoms associated with acetaldehyde accumulation accompanying ethanol consumption, or reduce the risk of diseases or disorders caused by consumption of ethanol, comprising administering 4-MP, or physiologically acceptable salts thereof, to subjects of these subpopulations.本發明提供投與4-甲基吡唑(4-MP)或其生理上可接受鹽至表現醇脫氫酶及醛脫氫酶基因之特異多態性之遺傳亞群個體之方法。本發明亦提供預防或改善乙醇不耐性、降低或改善飲用乙醇(ethanol consumption)伴隨之乙醛累積相關症狀、或降低由飲用乙醇引起疾病或失調症風險之方法,其包含投與4-MP或其生理上可接受鹽至此等亞群之個體。(無元件符號說明)
