Thomas E. DALEY,Elizabeth C. SQUIERS,Kin-Hung P. YU
申请号：
US15788504
公开号：
US20180098964A1
申请日:
2017.10.19
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Provided herein are methods of administering 4-methylpyrazole (4-MP), or physiologically acceptable salts thereof, to subjects of geneic subpopulations expressing specific polymorphisms of the alcohol dehydrogenase and aldehyde dehydrogenase genes. Also provided herein are methods to prevent or ameliorate ethanol intolerance, reduce or ameliorate symptoms associated with acetaldehyde accumulation accompanying ethanol consumption, or reduce the risk of diseases or disorders caused by consumption of ethanol, comprising administering 4-MP, or physiologically acceptable salts thereof, to subjects of these sub-populations.
