ELŻBIETA MAGDALENA WNUK,PAWEŁ LUCJAN NIEDZIAŁKOWSKI,TADEUSZ OSSOWSKI,JOANNA WIETRZYK
申请号：
PL408238
公开号：
PL408238A1
申请日:
2014.05.19
申请国别(地区):
PL
年份:
2015
代理人:
摘要：
the subject of the invention is wielocz\u0105steczkowe molecular systems containing rings 9,10 - antraquinone and receive wielocz\u0105steczkowych molecular systems containing rings 9,10 - antraquinone. the invention refers to a group of new cytostatic antibiotics inhibit cell division.wielocz\u0105steczkowy molecular system containing rings 9,10 - antraquinone is characterized by the fact that it is 1 - chloro - 8 - (4 - (8 - (piperazin-1-yl) - 9,10 - anthraquinone - 1 - yl) piperazin-1-yl) - 9,10 - anthraquinone, containing two molecules of piperazine and chlorine atom model 1.way to receive wielocz\u0105steczkowego molecular system containing rings 9,10 - antraquinone is that in order to obtain 1 - chloro - 8 - (4 - (8 - (piperazin-1-yl) - 9,10 - anthraquinone - 1 - yl) piperazin-1-yl) - 9,10-anthracenedione antraquinone, containing two molecules of piperazine and chlorine atom in ykorzystuje as substrates output 1.8 - dichloro - 9,10 - anthraquinone and piperazine.which carried out reaction in anhydrous ethanol or toluene environment in the environment by heating the reaction mixture to a temperature 80\u00b0c by time approximately 96 hours, after which the mixture poreakcyjnej the ethanol on the evaporator. the residue is dissolved in methylene chloride and is washed with water (3 x 200 ml).the organic layer dried anhydrous mgso4 and the solvent vaporized in the evaporator, after which the mixture obtained by the chemical reaction of compounds isolated using a columnar chromatography as a method of separation on silica gel using as el ent initially by methylene chloride.and then the methylene chloride and methanol with increasing gross gradient of methanol with the product efficiency of 80%.Przedmiotem wynalazku są wielocząsteczkowe układy molekularne zawierające pierścienie 9,10-antrachinonu i sposób otrzymywania wielocząsteczkowych układów molekularnych zawierających pierścienie 9,10-antrachinonu. Wynalazek dotyczy grupy nowych antybiotyków cytostatycznych ha
