Michael C. Heinrich,Christopher C. Corless,Jonathan A. Fletcher,George D. Demetri
申请号：
US12959588
公开号：
US08202969B2
申请日:
2010.12.03
申请国别(地区):
US
年份:
2012
代理人:
摘要：
This disclosure provides tyrosine kinase protein and nucleic acid variants, particularly PDGFRA variants, which are activating forms of these molecules and are linked to neoplasms and/or the development or progression of cancer. The disclosure further provides methods of diagnosis and prognosis, and development of new therapeutic agents using these molecules and fragments thereof, and kits for employing these methods and compositions.
