Thomas Spector,William Paul Peters,Donald W. Kufe,Brian Huber
申请号：
US11294643
公开号：
US08318756B2
申请日:
2005.12.05
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Methods for improved administration and dosing of DPD inhibitors in combination with 5-FU and/or 5-FU prodrugs are provided, comprising first administering to a patient in need thereof a DPD inhibitor that substantially eliminates activity of the enzyme and thereafter administering 5-FU or a 5-FU prodrug, wherein the level of 5-FU or 5-FU prodrug is in substantial excess of DPD inhibitor in the patient.
