INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY
发明人:
PARK, SUK HO,박석호,PARK, JONG OH,박종오,PARK, SUNG JUN,박성준
申请号：
KR1020120005924
公开号：
KR1020130085073A
申请日:
2012.01.18
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: A bacteria-based microrobot is provided to be able to maximize the therapeutic effect of drug as a clastic enzyme is expressed with the bacteria by the external stimulus, and, therefore, the drug is released from the microstructure when the microrobot reaches the cancer tissue or infarct tissue.CONSTITUTION: A bacteria-based microrobot (1) comprises a microstructure including natural polymer shell (11) and a drug (13) sealed in the shell and a disease target attenuated bacteria including a gene construct in which polynucleotide encoding the natural polymer clastic enzyme (21) capable of decomposing the natural polymer is connected to an inducible promoter in an operational manner The natural polymer is cellulose, methylcellulose, ethylcellulose, hemicellulose, lignin, starch, pectin, gelatin, collagen, chitosan, hyaluronic acid, heparin or alginic acid. The drug is an anti-cancer drug or an infarction treatment drug.COPYRIGHT KIPO 2013본 발명은 병소에서의 효과적인 약물방출을 달성하기 위하여, 천연고분자 쉘 및 그에 봉입된 약물 및/또는 치료용 박테리아를 포함하는 마이크로구조체 및 상기 마이크로구조체 표면에 부착되며 상기 천연고분자를 분해할 수 있는 천연고분자 분해효소를 암호화하는 폴리뉴클레오티드가 유도성 프로모터에 작동가능하게 연결된 유전자 컨스트럭트를 포함하는 질병 표적 약독화 박테리아를 포함하는 박테리아-기반 마이크로로봇을 제공한다.
