TANG, Kim,RENNIE, Glen Robert,LEE, Thomas Wai-Ho,NAKAI, Takashi,BARDEN, Timothy Claude,JIA, Lei,IYENGAR, Rajesh R.,JUNG, Joon,RENHOWE, Paul Allan,GERMANO, Peter,IM, G-Yoon Jamie,MERMERIAN, Ara,IYER, K
申请号：
CR20190101
公开号：
CR20190101A
申请日:
2017.09.01
申请国别(地区):
CR
年份:
2019
代理人:
摘要：
This note refers to soluble adhesives (GHC).1. Pharmaceutical preparations containing this substance and their use alone or in combination with one or more other preparations are used to treat various diseases. In this case, it is advisable to increase the concentration of nitrous oxide (non) and/or cyclic phosphate gloves.Or actively regulate track 1. Compounds are the present Disclosure Relations to Stimulators of Soluble Guangylate Cyclas (SGC).Pharmaceutical formulations include them and their uses, alone or in combination with one or more additional agents, for treating various diseases, where an increase in the concentration of nitric oxide (no) or an increase in the concentration of cycle guanosine monophosphate (CMP),Or both, or an upregulation of the NO pathway is desirable. The compounds are of formula (I).La presente descripción hace referencia a estimuladores de la guanilato ciclasa soluble (sGC), formulaciones farmacéuticas que los comprenden y sus usos, en solitario o en combinación con uno o más agentes adicionales, para el tratamiento de diversas enfermedades, donde sea conveniente un aumento de la concentración de óxido nítrico (NO) y/o un aumento de la concentración de guanosín monofosfato cíclico (cGMP), o una regulación positiva de la vía de NO. Los compuestos son de Fórmula IThe present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP), or both, or an upregulation of the NO pathway is desirable. The compounds are of Formula (I).
