AETERNA ZENTARIS GMBH;Æterna Zentaris GmbH;University of Montpellier II;Centre National de la Recherche Scientifique;University of Montpellier I
发明人:
申请号：
EP06776764.0
公开号：
EP1915149B1
申请日:
2006.08.11
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
The present invention provides novel triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors according to formula (I) that are useful in the treatment or prophylaxis of physiological and/or pathophysiological conditions in mammals, preferably humans, that are mediated by GHS receptors. The present invention further provides GHS receptor antagonists and agonists that can be used for modulation of these receptors and are useful for treating above conditions, in particular growth retardation, cachexia, short-, medium- and/or long term regulation of energy balance； short-, medium- and/or long term regulation (stimulation and/or inhibition) of food intake； adipogenesis/adiposity/obesity； body weight gain and/or reduction； tumor cell proliferation； inflammation and/or inflammatory effects.
