Jean Martinez;Aline Moulin;Luc Demange;Damien Boeglin;Jean-Alain Fehrentz;Daniel Perrissoud
发明人:
Daniel Perrissoud,Jean Martinez,Aline Moulin,Jean-Alain Fehrentz,Damien Boeglin,Luc Demange
申请号：
US12880774
公开号：
US08710089B2
申请日:
2010.09.13
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention provides novel triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors according to formula (I) that are useful in the treatment or prophylaxis of physiological and/or pathophysiological conditions in mammals, preferably humans, that are mediated by GHS receptors. The present invention further provides GHS receptor antagonists and agonists that can be used for modulation of these receptors and are useful for treating above conditions, in particular growth retardation, cachexia, short-, medium- and/or long term regulation of energy balance； short-, medium- and/or long term regulation (stimulation and/or inhibition) of food intake； adipogenesis, adiposity and/or obesity； body weight gain and/or reduction； diabetes, diabetes type I, diabetes type II, tumor cell proliferation； inflammation, inflammatory effects, gastric postoperative ileus, postoperative ileus and/or gastrectomy (ghrelin replacement therapy).
