METHODS FOR INCREASING THERMOGENIC ADIPOCYTES

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专利权人:

发明人:

John Knopf,Jasbir Seehra,Ravindra Kumar

申请号：

US15703007

公开号：

US20180162954A1

申请日:

2017.09.13

申请国别(地区):

US

年份:

2018

代理人:

摘要：

In certain aspects, the present invention provides compositions and methods for increasing thermogenic adipocytes (e.g., brown adipocytes or other UCP-1 expressing adipocytes) by administering an antagonist of an ActRIIB signaling pathway. Examples of such antagonists include ActRIIB polypeptides, anti-ActRIIB antibodies, anti-myostatin antibodies, anti-GDF3 antibodies, anti-Nodal, anti-activin, and anti-GDF11 antibodies. A variety of metabolic and other disorders may be treated by causing an increase in thermogenic adipocytes.

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