UNIVERSITAT DE VALÈNCIA;FUNDACIÓ PRIVADA INSTITUT DE RECERCA;INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS;UNIVERSIDADE DE SANTIAGO DE COMPOSTELA;FUNDACIÓ PRIVADA INSTITUT CATALÀ DE NANOTECNOLOGIA
发明人:
FRANCO PUNTES, VÍCTOR,DOMINGUEZ PUENTE, FERNANDO,ROMERO MARTINEZ, FRANCISCO MANUEL,GALLEGO RUBIO, OSCAR
申请号：
ES09768395
公开号：
ES2505890T3
申请日:
2009.12.15
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A conjugate of formula (I) NP-L-A (I) that has colloidal stability in a medium in which NP is a gold, silver or platinum nanoparticle； L is a linker of formula (II) or a stereoisomer thereof, which is attached to the NP nanoparticle by the sulfur atom； or L is a linker of formula (III) or a stereoisomer thereof, which is attached to the NP nanoparticle by the two sulfur atoms in which: X and Y independently represent a hydrocarbon chain (C2-C20), in the that at least one carbon atom is optionally substituted with a CO group or a heteroatom selected from the group consisting of O and N； and wherein the hydrocarbon chain (C2-C20) is optionally substituted with one or more substituents selected from the group consisting of halogen, OH, CONH2, CO2-alkyl (C1-C6) and -CHO； n and s independently represent a value from 0 to 1； p represents a value of 1 to 2； and A is a biradical platinum (II) selected from the group consisting of formula (IV), formula (V) and formula (VI) that includes any of the stereoisomers of all of them, in which the biradical is optionally in the form of a salt, and is attached to the linker L by the single-bond oxygen atom of the carboxyl groups with the proviso that: when in the linker of formula (II) or formula (III), n>； = 1 os >； = 1； the biradical (II) of platinum is attached to a linker molecule of formula (II) or formula (III), thus forming two COO-Pt bonds with the same linker molecule； and when in the crimp of formula (II) or formula (III), n>； = 0 or s>； = 0； the biradical (II) of platinum is attached to two independent crimp molecules of formula (II) or formula (III), thus forming a COO-Pt bond with each of these two crimp molecules； and at least 45% of the L linkers of formula (II) or formula (III) being in the form of free carboxyl groups.Un conjugado de fórmula (I) NP-L-A (I) que tiene estabilidad coloidal en un medio en la que NP es una nanopartícula de oro, plata o platino； L es un engarce de fórmula (II) o un estereoisómero d
