Victor Franco Puntes;Fernando Domíguez Puente;Óscar Gallego Rubio;Francisco Manuel Romero Martínez
发明人:
Victor Franco Puntes,Fernando Domíguez Puente,Francisco Manuel Romero Martínez,Óscar Gallego Rubio
申请号：
US13140347
公开号：
US09023370B2
申请日:
2009.12.15
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to conjugates of formula (I) having colloidal stability in a medium, wherein NP is a gold, silver or platinum nanoparticle； L is a linker selected from the group consisting of formula (II), formula (III), and a stereoisomer of any of the formulas (II) and (III), which is attached to the nanoparticle NP through sulfur atoms； wherein the meanings of X, n, p, Y and s are further specified in the description； and A is a platinum (II) biradical selected from the group consisting of formula (IV), formula (V) and formula (VI) including any of the stereoisomers of all of them, wherein the biradical is optionally in the form of a salt and is attached to the linker L through the single bonded oxygen atoms of the carboxyl groups. It also relates to a process for the preparation of the conjugates of formula (I) and to pharmaceutical compositions containing them. The conjugates of the invention are used for the treatment of cancer.
