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COMPOSITIONS AND METHODS INCLUDING ALKYL GLYCOSIDES FOR STABILIZING PROTEIN-CONTAINING COMPOSITIONS
专利权人:
ДЖЕНЕНТЕК; ИНК. (US)
发明人:
ЕСУЕ Осигве (US),ШАРМА Викас К. (US)
申请号:
RU2013103025/15
公开号:
RU2013103025A
申请日:
2011.06.23
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. An aqueous composition comprising an antibody and an alkyl glycoside having a CMC value of about 1.0 mM or more in water at 25 ° C. 2. The composition of claim 1, wherein the antibody is a monoclonal antibody. The composition of claim 1, wherein the alkyl glycoside is selected from the group consisting of n-hexyl-β-D-glucopyranoside, n-heptyl-β-D-glucopyranoside, n-octyl-β-D-glucopyranoside, n-nonyl-β -D-glucopyranoside, n-decyl-β-D-glucopyranoside, 3-cyclohexyl-1-propyl-β-D-glucoside, 3-cyclohexyl-1-butyl-β-D-glucoside, n-hexyl-β-D -Maltopyranoside, n-octyl-β-D-maltopyranoside, n-nonyl-β-D-maltopyranoside, n-decyl-β-D-maltopyranoside, cyclohexylmethyl-β-D-maltoside, 2-cyclohexylethyl-β-D-maltoside , 3-cyclohexylpropyl-β-D-maltoside, 4-cyclohexylbutyl-β-D-maltoside and 5-cyclohex silpentyl-β-D-maltoside. 4. The composition of claim 1, wherein the alkyl glycoside is n-octyl-β-D-glucopyranoside. The composition of claim 1, wherein the alkyl glycoside is n-decyl-β-D-glucopyranoside. The composition of claim 1, wherein the alkyl glycoside is n-decyl-β-D-maltopyranoside. The composition of claim 1, wherein the alkyl glycoside is n-hexyl-β-D-glucopyranoside. A composition according to claim 1, containing an amount of said alkyl glycoside inhibiting agitation caused by stirring. A composition according to claim 1, containing an amount of said alkyl glycoside that prevents oxidation. The composition of claim 1, wherein the alkyl glycoside is present in a concentration that is less than the CMC of the alkyl glycoside in water at 25 ° C. A composition according to claim 1, which is stable at a temperature of about 2-8 ° C for at least one year. The composition according to claim 1, which is stable p1. Водная композиция, содержащая антитело и алкилгликозид, имеющий значение CMC около 1,0 мМ или более в воде при 25°C.2. Композиция по п.1, в которой антитело представляет собой моноклональное антитело.3. Композиция по п.1, в которой алкилгликозид выбран из группы, состоящей из
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