The present invention relates to a new class of compounds, compositions and applications thereof as inhibitors of kinases such as TRK, c-MET, AXL, MER and/or VEGFR2. Specifically, the present invention provides a class of compounds (as shown in formula (1)) or isomers, solvates, and hydrates that have potent inhibitory activity of TRK, c-MET, AXL, MER and/or VEGFR2 and other kinases , Pharmaceutically acceptable salts, prodrugs, and pharmaceutical compositions containing the compounds. The invention also discloses the application of the compound or the pharmaceutical composition of the invention in the preparation of a medicine, which is used for the treatment of autoimmune diseases or cancer.本發明涉及作為TRK、c-MET、AXL、MER和/或VEGFR2等激酶的抑制劑的一類新化合物、組合物及其應用。具體地，本發明提供了一類具有強力抑制TRK、c-MET、AXL、MER和/或VEGFR2等激酶的活性的化合物（如式（1）所示）或其異構體、溶劑化物、水合物、在藥學上可接受的鹽、前藥，及包含所述化合物的藥物組合物。本發明還公開了本發明化合物或藥物組合物在製備藥物中的應用，該藥物用於治療自身免疫疾病或癌症。
