The current invention involves a series of fully recombinant multimerized forms of immunoglobulin Fc which thereby present polyvalent immunoglobulin Fc to immune cell receptors. The fusion proteins exist as both homodimeric and highly ordered multimeric fractions, termed stradomers. The invention involves stradomers that increase multimerization and bind preferentially to complement and that are useful in the treatment and prevention of disease.本發明涉及免疫球蛋白Fc之一系列完全重組多聚體化形式，其藉此向免疫細胞受體呈遞多價免疫球蛋白Fc。融合蛋白以均二聚體及高度有序多聚體溶離份兩者之形式存在，稱為斯特拉多體(stradomer)。本發明涉及提高多聚合且優先結合至補體之斯特拉多體且其適用於治療及預防疾病。
