The current invention involves a series of fully recombinant multimerized forms of immunoglobulin Fc which thereby present polyvalent immunoglobulin Fc to immune cell receptors. The fusion proteins exist as both homodimeric and highly ordered multimeric fractions, termed stradomers. In comparison to the homodimeric fraction, purified multimeric stradomers have higher affinity and avidity for FcγRs with slower dissociation and are useful in the treatment and prevention of disease. The current invention demonstrates that directly linking IgG1 Fc regions to multimerization domains leads to enhanced multimerization and biological activity.本發明涉及免疫球蛋白Fc之一系列完全重組多聚體化形式，藉此將多價免疫球蛋白Fc呈遞至免疫細胞受體。該等融合蛋白以同源二聚體(homodimeric)部分及稱為斯塔都聚體(stradomers)之高序多聚體部分二者存在。與該同源二聚體部分相比，經純化多聚體斯塔都聚體對FcγRs具有較高親和力及結合性(avidity)且解離較慢並可用於治療及預防疾病。本發明顯示，將IgG1 Fc區直接連接至多聚體化結構域會增強多聚體化及生物活性。
