REGULATION D'EXPRESSION GENIQUE PAR POLYADENYLATION MODULEE PAR APTAMERE

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专利权人:

MEIRAGTX UK II LIMITED

发明人:

VOLLES, MICHAEL J.,DANOS, OLIVIER F.,GUO, XUECUI

申请号：

CA3048620

公开号：

CA3048620A1

申请日:

2017.02.02

申请国别(地区):

CA

年份:

2017

代理人:

摘要：

The invention provides polynucleotide constructs for the regulation of gene expression by aptamer-based modulation of U1 small nuclear ribonucleoprotein (snRNP)-mediated suppression of polyadenylation and methods of using the constructs to regulate gene expression in response to the presence or absence of a ligand that binds the aptamer. The polynucleotide construct contains a U1 binding site in the context of a riboswitch comprising an effector region and an aptamer such that when the aptamer binds a ligand, target gene expression occurs.

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