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Regulation of gene expression through aptamer-modulated polyadenylation
专利权人:
MeiraGTx UK II Limited
发明人:
Volles, Michael J.,Danos, Olivier F.,Guo, Xuecui
申请号:
AU2017213835
公开号:
AU2017213835A1
申请日:
2017.02.02
申请国别(地区):
AU
年份:
2018
代理人:
摘要:
The invention provides polynucleotide constructs for the regulation of gene expression by aptamer-based modulation of U1 small nuclear ribonucleoprotein (snRNP)-mediated suppression of polyadenylation and methods of using the constructs to regulate gene expression in response to the presence or absence of a ligand that binds the aptamer. The polynucleotide construct contains a U1 binding site in the context of a riboswitch comprising an effector region and an aptamer such that when the aptamer binds a ligand, target gene expression occurs.
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中国工程科技知识中心
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