The present invention relates to the pharmaceutical preparations of general formula I, it can be used for treating and/or preventing mammal, especially can be used for treating disease, such as cancer to inhibitor NF keyboards inducible kinase (NIK-is also referred to as MAP3K14), inflammatory disease, dysbolism and autoimmune disease. The present invention also relates to the Pharmaceutical compositions comprising such compound, and using the compound or pharmaceutical composition for preventing or treating disease, such as cancer, inflammatory disease, dysbolism, including obesity and diabetes and autoimmune disease.