The present invention relates to the pharmaceutical agents that can be used for being treated and/or being prevented in mammals, and relate in particular to the inhibitor of NF- κ B inducible kinases (NIK- is also referred to as MAP3K14), the grade inhibitor can be used for treating following disease, such as cancer, inflammatory disorder, metabolism disorder and autoimmune disease. Present invention is alternatively directed to the pharmaceutical compositions comprising such compound And it is used to prevent or treat the purposes of disease, the metabolism disorder and autoimmune disease of the diseases such as this such as cancer, inflammatory disorder including obesity and diabetes for such compound or pharmaceutical composition.
