The present invention discloses novel uses of specific menthol-derivative compounds ofFormula1, and compositions thereof, for methods of providing oral and systemic health care benefits, and methods of up-regulating or down-regulating periodontal disease metabolites:wherein, X is an oxygen atom or an NH radical； and R is an unsubstituted or substituted aryl or aliphatic radical.In some embodiments, the oral and systemic health care benefits include biofilm anti-attachment, anti-inflammation, anti-oxidant, anti-bone loss, and anti-microbial benefits. ln some embodiments, the periodontal disease metabolites correspond to healthy and/or diseased oral status and allow differential diagnosis of oral health.本發明係揭示特定的式I之醇衍生物化合物之新穎的用途，及其組成物，提供口腔及全身性健康照護利益之方法以及上調或下調牙周疾病代謝物之方法：其中，X為氧原子或NH基；及R為未取代或經取代之芳基或脂族基。在一些實施例中，口腔及全身性健康照護之利益包括生物膜抗黏附、抗發炎、抗氧化、抗骨質流失及抗微生物利益。在一些實施例中，牙周疾病代謝物相應於健康及/或患病的口腔狀況並能作口腔健康之鑑別診斷。
