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Prodrugs of 1,4-benzodiazepinone compounds
专利权人:
发明人:
Ashvinikumar V. Gavai,Wen-Ching Han,Brian E. Fink,Victor R. Guarino
申请号:
US14429930
公开号:
US09273075B2
申请日:
2013.09.20
申请国别(地区):
US
年份:
2016
代理人:
摘要:
Disclosed are compounds of Formula (I) and salts thereof, wherein: a) R1 is H or CH3, and R2 is Ry or b) R1 is Rx and R2 is H wherein Rx and Ry are disclosed herein. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are prodrugs of compounds that are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer.
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