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PSMA and CD3 bispecific T cell engaging antibody constructs
专利权人:
AMGEN RESEARCH (MUNICH) GMBH
发明人:
Tobias Raum,Markus Münz,Johannes Brozy,Peter Kufer,Patrick Hoffmann,Matthias Friedrich,Benno Rattel,Pamela Bogner,Andreas Wolf,Cornelius Pompe
申请号:
US15422661
公开号:
US10781264B2
申请日:
2017.02.02
申请国别(地区):
US
年份:
2020
代理人:
摘要:
The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to PSMA, a second domain binding to an extracellular epitope of the human and the Macaca CD3ε chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
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