We report a method of detecting a pathological body state of a patient, comprising receiving a body signal of the patient determining a BDV from said body signal determining an activity level of said patient determining a value range for said BDV for said patient, based at least in part on said activity level comparing said BDV to said value range and detecting a pathological state when said BDV is outside said value range. We also report a medical device system configured to implement the method. We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.
