University of Hertfordshire Higher Education Corporation
发明人:
Sharon Rossiter,Stewart Brian Kirton,Ramatoulie Camara
申请号：
GB201608085
公开号：
GB2543375A
申请日:
2016.05.09
申请国别(地区):
GB
年份:
2017
代理人:
摘要：
A compound of formula (A) or a pharmaceutically acceptable salt, solvate, hydrate, polymorph, prodrug, codrug, cocrystal, tautomer, racemate, stereoisomer or mixture thereof: wherein X is nitro or hydrogen； Y is hydrogen or a side group. Preferably, Y is selected from H, amino, amide, ester, carboxy and its esters and amides, alkyl, alkenyl, alkynyl, cycloalkyl, alkaryl, aryl, heterocyclic or heteroaryl groups, all of which may be optionally substituted with heteroatoms and/or side groups, and wherein any chains may be straight or branched. More preferably, Y is optionally substituted imidazolyl, optionally substituted pyrazolyl, optionally substituted triazolyl or tetrazolyl. More preferably, Y is phenyl or substituted phenyl. The compounds of formula (A) are inhibitors of S100P/RAGE and are useful in the treatment of cancer, in particular pancreatic cancer.
