HADIDA RUAH SARAH S.,HAZLEWOOD ANNA R.,GROOTENHUIS PETER D.J.,VAN GOOR FREDRICK F.,SINGH ASHVANI K.,ZHOU JINGLAN,MCCARTNEY JASON
申请号：
NZ59839305
公开号：
NZ598393A
申请日:
2005.06.24
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
Disclosed are N-(4-tert-butyl-2-phenyl-5-hydroxyphenyl)-1,4-dihydro-4-oxo-quinoline-3-carboxamide derivatives as represented by the general formula V-A-I, or a pharmaceutically acceptable salt thereof, wherein: WRW2 is a phenyl ring optionally substituted with up to three substituents selected from -OR&rsquo；, -CF3, -OCF3, SR&rsquo；, S(O)R&rsquo；, SO2R&rsquo；, halo, CN, -COOR&rsquo；, -(CH2)OR&rsquo；, CH2CN, optionally substituted phenyl or phenoxy, -N(R&rsquo；)(R&rsquo；), -NR&rsquo；C(O)OR&rsquo；, -NR&rsquo；C(O)R&rsquo；, -(CH2)2N(R&rsquo；)(R&rsquo；), or -(CH2)N(R&rsquo；)(R&rsquo；)； WRW4 is straight or branched alkyl； WRW5 is OH； R&rsquo； is independently selected from hydrogen or an optionally substituted group selected from an aliphatic group, cycloalkyl or phenyl； X is a bond； and RX is hydrogen.
