The present invention provides an oral pharmaceutical formulation comprising coated spheroids of a kinase inhibitor such as neratinib, which formulation is designed to reduce or eliminate side effects associated with existing oral formulations of kinase inhibitors.本發明提供一種口服藥學調製劑,其包含一種激酶抑制劑(諸如諾拉替尼(neratinib))之經加衣球,該調製劑係設計用以減輕或除去與激酶抑制劑之現有口服調製劑有關的副作用。