PROBLEM TO BE SOLVED: To provide an orally rapidly disintegrating tablet characterized in that the tablet can be produced in a conventional tablet manufacturing facility and has a satisfactory level of hardness for practical applications, and the change in properties of the tablet (i.e., decrease in hardness of the tablet, and delay of the disintegration time of the tablet in the oral cavity) are rarely caused by factors such as humidity.SOLUTION: An orally rapidly disintegrating tablet has hardness of 40 N or more, can be disintegrated in the oral cavity within 60 seconds, and is produced by compressing of a mixture of (a) an active ingredient, (b) an excipient having good water wettability, (c) a water-insoluble polymer that is well compactible and does not substantially cause a decrease in the water wettability of the excipient and (d) a disintegrating agent.【課題】本発明は、通常の錠剤製造設備で製造が可能で、実用上充分な硬度を有し、また、湿度等の要因による特性の変化（錠剤の硬度低下及び口腔内での速崩時間の遅延）を生じ難いという特長を有する口腔内速崩壊性錠を提供する。【解決手段】本発明は、硬度４０Ｎ以上で口腔内での崩壊時間が６０秒以内である口腔内速崩壊性錠であって、（ａ）活性成分；（ｂ）水への濡れ性が良好な賦形剤；（ｃ）成形性が良好で前記賦形剤の水への濡れ性を実質的に低下させない水不溶性高分子；及び（ｄ）崩壊剤の混合物を圧縮成形して得られることを特徴とする当該口腔内速崩壊性錠に関する。【選択図】なし
